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Pakistan-born aspiring comedian Kumail connects with grad student Emily after one of his standup sets. However, what they thought would be just a one-night stand blossoms into the real thing, which complicates the life that is expected of Kumail by his traditional Muslim parents. Then Emily is beset with a mysterious illness, forcing Kumail to navigate the medical crisis with her parents, who he's never met, while dealing with the emotional tug-of-war between his family and his heart.