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While flying to his father's funeral in rural Appalachia, an intense storm causes Marquis to lose control of the plane carrying himself and his family. He soon awakens wounded, alone and trapped in Ms. Eloise's attic. Eloise claims she can nurse him back to health with a hoodoo figure she's made from his blood and skin. Unable to call for help, Marquis desperately tries to break free from her dark magic and save his family from a sinister ritual before the rise of the blood moon.